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The use of estrogens in humans (or animals) is quite rare, and the effect of estrogens on pregnancy is extremely small (the few experiments conducted actually had low effects, possibly due to the severe lack of control, or due to the fact that progesterone can suppress some important hormones as well, such as progesterone-binding globulin/glucuronide and thyroid hormones).
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Another factor in the use of progesterone during the first trimester is that progesterone is metabolized by the liver and glucuronidation occurs with other drugs. But some progesterone is also created by the liver in response to progesterone. The liver (which produces progesterone) can oxidize prostaglandin E2 into prostaglandin B2, so prostaglandin E2 can be converted to a form of progesterone in tissues in which it is present
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